Locomotor activity depends on β-arrestin recruitment by the dopamine D1 receptor in the striatal D1-D3 receptor heteromer

Several dopaminergic compounds, including the clinically used pramipexole, are labelled as preferential dopamine D3 receptor (D3R) agonists based on their moderately higher affinity for the D3R versus other D2-like receptor subtypes. In rodents, these compounds typically produce locomotor depression...

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Principais autores:	Alexandra H. Evans, Marc Ciruela-Jardí, William Rea, Bradley M. Keegan, Marjorie R. Levinstein, Alessandro Bonifazi, Jianjing Cao, Shelley N. Jackson, Lei Shi, Nil Casajuana-Martin, Ning-Sheng Cai, Vicent Casadó, Christopher J. Earley, Amy H. Newman, Michael Michaelides, Leonardo Pardo, Estefanía Moreno, Sergi Ferré
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2025-08-01
Series:	Pharmacological Research
Assuntos:	Dopamine D1 receptor Dopamine D3 receptor Heteromers Striatum β-arrestin Locomotor activity
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S1043661825002518
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