The ability of alphavirus replicases to synthesize non-viral type I interferon-inducing RNAs correlates with viral RNA synthesis and has a diverse impact on virus replication and pathogenicity

ABSTRACT Alphaviruses have positive-strand RNA genomes that mimic cellular mRNAs, and their translation results in the synthesis of nonstructural (ns) polyprotein, the precursor of viral replicase. The ns polyprotein is processed by its protease activity to form an early replicase complex, responsib...

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Principais autores:	Ailar Omler, Anna Rutmane, Suresh Mahalingam, Andres Merits
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	American Society for Microbiology 2026-02-01
סדרה:	Journal of Virology
נושאים:	alphavirus interferons double-stranded RNA viral RNA replicase type I interferon self-amplifying RNA vaccines
גישה מקוונת:	https://journals.asm.org/doi/10.1128/jvi.02162-25
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