The ability of alphavirus replicases to synthesize non-viral type I interferon-inducing RNAs correlates with viral RNA synthesis and has a diverse impact on virus replication and pathogenicity

ABSTRACT Alphaviruses have positive-strand RNA genomes that mimic cellular mRNAs, and their translation results in the synthesis of nonstructural (ns) polyprotein, the precursor of viral replicase. The ns polyprotein is processed by its protease activity to form an early replicase complex, responsib...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Ailar Omler, Anna Rutmane, Suresh Mahalingam, Andres Merits
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology 2026-02-01
Schriftenreihe:	Journal of Virology
Schlagworte:	alphavirus interferons double-stranded RNA viral RNA replicase type I interferon self-amplifying RNA vaccines
Online-Zugang:	https://journals.asm.org/doi/10.1128/jvi.02162-25
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!