Endoplasmic reticulum stress-dependent regulation of the expression of serine hydroxymethyltransferase 2 in glioblastoma cells

Objective. Serine hydroxymethyltransferase (SHMT2) plays a multifunctional role in mitochondria (folate-dependent tRNA methylation, translation, and thymidylate synthesis). The endoplasmic reticulum stress, hypoxia, and glucose and glutamine supply are significant factors of malignant tumor growth i...

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Hlavní autoři:	Minchenko Oleksandr H., Sliusar Myroslava Y., Khita Olena O., Viletska Yuliia M., Luzina Olha Y., Danilovskyi Serhiy V., Minchenko Dmytro O.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Sciendo 2024-01-01
Edice:	Endocrine Regulations
Témata:	ern1 knockdown hypoxia nutrient deprivation shmt2 gene expression u87mg cells
On-line přístup:	https://doi.org/10.2478/enr-2024-0016
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