A novel molecule ZYZ329 targeting histone methyltransferase SMYD3 suppresses pathological angiogenesis via the driven mitochondrial ROS/HIF-1α/VEGFA axis

Abstract Background The histone methyltransferase SMYD3 (SET and MYND domain containing 3) is critical for vascular homeostasis and may be implicated in pathological angiogenesis. However, its mechanism remains elusive, and targeted inhibitors are in early-stage development. We aim to clarify whethe...

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Detalhes bibliográficos

Principais autores:	Qing Ye, Jianghong Cai, Xianneng Lu, Qi Zhu, Qixiu Li, Mi Ren, Qian Ding, Yicheng Mao, Yi Zhun Zhu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-02-01
coleção:	Journal of Translational Medicine
Assuntos:	SMYD3 Angiogenesis ZYZ329 HIF-1α Endothelial cell
Acesso em linha:	https://doi.org/10.1186/s12967-025-07580-2
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