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The SMYD3-dependent H3K4me3 status of IGF2 intensifies local Th2 differentiation in CRSwNP via positive feedback

Abstract Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous and common upper airway disease divided into various inflammatory endotypes. Recent epidemiological findings showed a T helper 2 (Th2)-skewed dominance in CRSwNP patients. Histone modification alterations can regulate tran...

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Principais autores: Lei Yu, Yi Wei, Tong Lu, Zhengqi Li, Shimin Lai, Yan Yan, Changhui Chen, Weiping Wen
Format: Artigo
Jezik:Inglês
Izdano: BMC 2023-11-01
Serija:Cell Communication and Signaling
Teme:
Online dostop:https://doi.org/10.1186/s12964-023-01375-y
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