Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance
Polycomb repressive complex 2 (PRC2) mediates gene silencing through chromatin reorganization by methylation of histone H3 lysine 27 (H3K27). Here, the authors present crystal structures of the inhibitor-bound wild-type and a mutant form of PRC2.
Gorde:
| Egile Nagusiak: | , , , , , , , , , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Nature Portfolio
2016-04-01
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| Saila: | Nature Communications |
| Sarrera elektronikoa: | https://doi.org/10.1038/ncomms11384 |
| Etiketak: |
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