Point mutations in c-Myc uncouple neoplastic transformation from multiple other phenotypes in rat fibroblasts.

Deregulation of c-Myc (Myc) occurs in many cancers. In addition to transforming various cell types, Myc also influences additional transformation-associated cellular phenotypes including proliferation, survival, genomic instability, reactive oxygen species production, and metabolism. Although Myc is...

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Autors principals:	J Anthony Graves, Kristi Rothermund, Tao Wang, Wei Qian, Bennett Van Houten, Edward V Prochownik
Format:	Artigo
Idioma:	Inglês
Publicat:	Public Library of Science (PLoS) 2010-10-01
Col·lecció:	PLoS ONE
Accés en línia:	http://europepmc.org/articles/PMC2965668?pdf=render
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