Loss of MBNL1-mediated retrograde BDNF signaling in the myotonic dystrophy brain
Abstract Reduced brain volume including atrophy in grey and white matter is commonly seen in myotonic dystrophy type 1 (DM1). DM1 is caused by an expansion of CTG trinucleotide repeats in the 3’ untranslated region (UTR) of the Dystrophia Myotonica Protein Kinase (DMPK) gene. Mutant DMPK mRNA contai...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
BMC
2023-03-01
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| Colección: | Acta Neuropathologica Communications |
| Materias: | |
| Acceso en línea: | https://doi.org/10.1186/s40478-023-01540-x |
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