Altered levels of the splicing factor muscleblind modifies cerebral cortical function in mouse models of myotonic dystrophy

Myotonic dystrophy (DM) is a progressive, multisystem disorder affecting skeletal muscle, heart, and central nervous system. In both DM1 and DM2, microsatellite expansions of CUG and CCUG RNA repeats, respectively, accumulate and disrupt functions of alternative splicing factors, including musclebli...

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Detalhes bibliográficos

Principais autores:	Gang Chen, Russell E. Carter, John D. Cleary, Tammy S. Reid, Laura P. Ranum, Maurice S. Swanson, Timothy J. Ebner
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2018-04-01
coleção:	Neurobiology of Disease
Assuntos:	Corpus callosum flavoprotein MBNL Microsatellite repeats Myotonic dystrophy
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S0969996118300032
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