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Lazertinib improves the efficacy of chemotherapeutic drugs in ABCB1 or ABCG2 overexpression cancer cells in vitro, in vivo, and ex vivo

Multidrug resistance (MDR) is the major cause of chemotherapy failure, which is usually caused by the overexpression of ATP-binding cassette (ABC) transporters such as ABCB1 and ABCG2. To date, no MDR modulator has been clinically approved. Here, we found that lazertinib (YH25448; a novel third-gene...

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Main Authors: Yingfang Fan, Tian Tao, Zhixing Guo, Kenneth Kin Wah To, Da Chen, Shaocong Wu, Chuan Yang, Jinsui Li, Min Luo, Fang Wang, Liwu Fu
Format: Artigo
Language:Inglês
Published: Elsevier 2022-03-01
Series:Molecular Therapy: Oncolytics
Subjects:
multidrug resistance
ABCB1
ABCG2
cancer
lazertinib
EGFR
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770522000237
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