Lazertinib improves the efficacy of chemotherapeutic drugs in ABCB1 or ABCG2 overexpression cancer cells in vitro, in vivo, and ex vivo

Multidrug resistance (MDR) is the major cause of chemotherapy failure, which is usually caused by the overexpression of ATP-binding cassette (ABC) transporters such as ABCB1 and ABCG2. To date, no MDR modulator has been clinically approved. Here, we found that lazertinib (YH25448; a novel third-gene...

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Detalhes bibliográficos

Principais autores:	Yingfang Fan, Tian Tao, Zhixing Guo, Kenneth Kin Wah To, Da Chen, Shaocong Wu, Chuan Yang, Jinsui Li, Min Luo, Fang Wang, Liwu Fu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2022-03-01
coleção:	Molecular Therapy: Oncolytics
Assuntos:	multidrug resistance ABCB1 ABCG2 cancer lazertinib EGFR
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2372770522000237
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