Biophysical and biochemical characterization of a VHH-based IgG-like bi- and trispecific antibody platform

Here, we report the characterization of a VHH-derived IgG-like bi- and trispecific antibody platform that essentially relies on the replacement of the VH and VL regions of a conventional antibody by two independently functioning VHH domains. Consequently, a VHH is engrafted onto constant region CH1...

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Autores principales:	Lukas Pekar, Michael Busch, Bernhard Valldorf, Steffen C. Hinz, Lars Toleikis, Simon Krah, Stefan Zielonka
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Taylor & Francis Group 2020-01-01
Colección:	mAbs
Materias:	Antibody engineering bispecific antibody camelid IgG-like nanobody single-domain antibody
Acceso en línea:	https://www.tandfonline.com/doi/10.1080/19420862.2020.1812210
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