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Inhibiting UCH-L5: Rational Design of a Cyclic Ubiquitin-Based Peptide Inhibitor

The ubiquitin-proteasome system is an essential regulator of many cellular processes including controlling protein homeostasis. The degradation of proteins by the multi-subunit proteasome complex is tightly regulated through a series of checkpoints, amongst which are a set of deubiquitinating protea...

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Bibliografiske detaljer
Principais autores: Dharjath S. Hameed, Huib Ovaa, Gerbrand J. van der Heden van Noort, Aysegul Sapmaz
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2022-05-01
Serier:Frontiers in Molecular Biosciences
Fag:
Online adgang:https://www.frontiersin.org/articles/10.3389/fmolb.2022.866467/full
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