Sunitinib-mediated inhibition of STAT3 in skeletal muscle and spinal cord does not affect the disease in a mouse model of ALS

Variability in disease onset and progression is a hallmark of amyotrophic lateral sclerosis (ALS), both in sporadic and genetic forms. Recently, we found that SOD1-G93A transgenic mice expressing the same amount of mutant SOD1 but with different genetic backgrounds, C57BL/6JOlaHsd and 129S2/SvHsd, s...

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मुख्य लेखकों:	Massimo Tortarolo, Andrea David Re Cecconi, Laura Camporeale, Cassandra Margotta, Giovanni Nardo, Laura Pasetto, Valentina Bonetto, Mariarita Galbiati, Valeria Crippa, Angelo Poletti, Rosanna Piccirillo, Caterina Bendotti
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	Elsevier 2024-09-01
श्रृंखला:	Neurobiology of Disease
विषय:	Amyotrophic lateral sclerosis STAT3, muscle atrophy Sunitinib SOD1 Disease progression Atrogenes
ऑनलाइन पहुंच:	http://www.sciencedirect.com/science/article/pii/S0969996124001761
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