C9orf72-ALS mutation drives basal mitophagy impairments in iNeurons
IntroductionALS is a neurodegenerative disorder characterized by progressive upper and lower motor neuron loss. A GGGGCC hexanucleotide repeat expansion (HRE) in the C9orf72 gene is the most common mutation found in populations of European descent. Mitochondrial dysfunction has been observed in C9or...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
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Frontiers Media S.A.
2026-02-01
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| Schriftenreihe: | Frontiers in Cellular Neuroscience |
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| Online-Zugang: | https://www.frontiersin.org/articles/10.3389/fncel.2026.1731669/full |
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