Mitochondrial ATP Depletion Disrupts Caco-2 Monolayer Integrity and Internalizes Claudin 7

Objective:In vivo studies suggest that intestinal barrier integrity is dependent on mitochondrial ATP production. Here, we aim to provide mechanistic support, using an in vitro model mimicking the oxidative in vivo situation.Methods: Human Caco-2 cells were cultured for 10 days in culture flasks or...

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Bibliografske podrobnosti

Principais autores:	Lonneke M. JanssenDuijghuijsen, Sander Grefte, Vincent C. J. de Boer, Lara Zeper, Dorien A. M. van Dartel, Inge van der Stelt, Melissa Bekkenkamp-Grovenstein, Klaske van Norren, Harry J. Wichers, Jaap Keijer
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2017-10-01
Serija:	Frontiers in Physiology
Teme:	Caco-2 permeability mitochondria intestinal epithelium galactose tight junctions
Online dostop:	http://journal.frontiersin.org/article/10.3389/fphys.2017.00794/full
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