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Tumour cell-expressed PD-L1 reprograms lipid metabolism via EGFR/ITGB4/SREBP1c signalling in liver cancer

Background & Aims: The programmed death-ligand 1 (PD-L1) is a major co-inhibitory checkpoint factor that controls T-cell activities in tumours. PD-L1 is expressed on immune cells and tumour cells. Whether tumour cell-expressed PD-L1 affects tumour cells in an immune cell-independent fashion rema...

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Principais autores: Man Zhao, Hongfeng Yuan, Guang Yang, Yufei Wang, Yanan Bu, Huihui Zhang, Lina Zhao, Pan Lv, Haolin Yun, Yu Geng, Jinyan Feng, Chunyu Hou, Shuai Wang, Ningning Zhang, Wei Lu, Xiaodong Zhang
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2024-04-01
Serier:JHEP Reports
Fag:
PD-L1
Tumours
Lipid metabolism reprogramming
EGFR
ITGB4
SREBP1c
Online adgang:http://www.sciencedirect.com/science/article/pii/S2589555924000107
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