Design, Synthesis, and Evaluation of Novel Immunomodulatory Small Molecules Targeting the CD40–CD154 Costimulatory Protein-Protein Interaction

We report the design, synthesis, and testing of novel small-molecule compounds targeting the CD40–CD154 (CD40L) costimulatory interaction for immunomodulatory purposes. This protein-protein interaction (PPI) is a TNF-superfamily (TNFSF) costimulatory interaction that is an important therapeuti...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Damir Bojadzic, Jinshui Chen, Oscar Alcazar, Peter Buchwald
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2018-05-01
Schriftenreihe:	Molecules
Schlagworte:	costimulation drug design immune modulation protein-protein interaction small molecule TNF superfamily
Online-Zugang:	http://www.mdpi.com/1420-3049/23/5/1153
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