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Design, Synthesis, and Evaluation of Novel Immunomodulatory Small Molecules Targeting the CD40–CD154 Costimulatory Protein-Protein Interaction

We report the design, synthesis, and testing of novel small-molecule compounds targeting the CD40–CD154 (CD40L) costimulatory interaction for immunomodulatory purposes. This protein-protein interaction (PPI) is a TNF-superfamily (TNFSF) costimulatory interaction that is an important therapeuti...

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Principais autores: Damir Bojadzic, Jinshui Chen, Oscar Alcazar, Peter Buchwald
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2018-05-01
Serier:Molecules
Fag:
costimulation
drug design
immune modulation
protein-protein interaction
small molecule
TNF superfamily
Online adgang:http://www.mdpi.com/1420-3049/23/5/1153
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