Response Surface Methodology-Optimized Ultrasonic-Assisted Extraction Combined with Folin–Ciocalteu Assay for Total Polyphenol Determination in Grape Seeds: Development and Application

A robust Folin–Ciocalteu method, coupled with an optimized ultrasonic-assisted extraction, was established for accurate quantification of total polyphenols in high-oil grape seed matrices, where lipid interference and low extraction efficiency have been persistent challenges. Samples were first defa...

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Autori principali:	Chujun Li, Ruiqi Liu, Linlin Meng, Yuxin Meng, Shuang Xu, Xin Wang, Lihong Wang, Tao Lan, Tong Zhou
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2026-03-01
Serie:	Applied Sciences
Soggetti:	grape seeds total polyphenols Folin–Ciocalteu method single-factor test response surface methodology
Accesso online:	https://www.mdpi.com/2076-3417/16/7/3306
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