Mechanistic investigation of flavonoid-mediated inhibition of N-methyl-N-nitrosourea-induced mutagenicity via noncovalent DNA binding

Abstract Background Previous research using the Ames assay showed that licoricidin (LCD) and isoliquiritigenin (ILTG) can block mutations caused by N-methyl-N-nitrosourea (MNU) in Salmonella typhimurium (S. typhimurium) TA1535. With the aim to clarify the antimutagenic mechanism of these flavonoids,...

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Autors principals:	Chisato Matsuoka, Nao Takatama, Takuya Muraoka, Keiko Inami
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2026-06-01
Col·lecció:	Genes and Environment
Matèries:	Antimutagenicity Isoliquiritigenin Licoricidin N 3-methyladenine O 6-methylguanine N-methyl-N-nitrosourea
Accés en línia:	https://doi.org/10.1186/s41021-026-00361-3
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