Mechanistic investigation of flavonoid-mediated inhibition of N-methyl-N-nitrosourea-induced mutagenicity via noncovalent DNA binding

Abstract Background Previous research using the Ames assay showed that licoricidin (LCD) and isoliquiritigenin (ILTG) can block mutations caused by N-methyl-N-nitrosourea (MNU) in Salmonella typhimurium (S. typhimurium) TA1535. With the aim to clarify the antimutagenic mechanism of these flavonoids,...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Chisato Matsuoka, Nao Takatama, Takuya Muraoka, Keiko Inami
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-06-01
coleção:	Genes and Environment
Assuntos:	Antimutagenicity Isoliquiritigenin Licoricidin N 3-methyladenine O 6-methylguanine N-methyl-N-nitrosourea
Acesso em linha:	https://doi.org/10.1186/s41021-026-00361-3
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!