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Protein domain-level landscape of cancer-type-specific somatic mutations.

Identifying driver mutations and their functional consequences is critical to our understanding of cancer. Towards this goal, and because domains are the functional units of a protein, we explored the protein domain-level landscape of cancer-type-specific somatic mutations. Specifically, we systemat...

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Autori principali: Fan Yang, Evangelia Petsalaki, Thomas Rolland, David E Hill, Marc Vidal, Frederick P Roth
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science (PLoS) 2015-03-01
Serie:PLoS Computational Biology
Accesso online:http://europepmc.org/articles/PMC4368709?pdf=render
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