Design of quinoline SARS-CoV-2 papain-like protease inhibitors as oral antiviral drug candidates

Abstract The ever-evolving SARS-CoV-2 variants necessitate the development of additional oral antivirals. This study presents the systematic design of quinoline-containing SARS-CoV-2 papain-like protease (PLpro) inhibitors as potential oral antiviral drug candidates. By leveraging the recently disco...

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Detalhes bibliográficos

Principais autores:	Prakash Jadhav, Xueying Liang, Ahmadullah Ansari, Bin Tan, Haozhou Tan, Kan Li, Xiang Chi, Alexandra Ford, Francesc Xavier Ruiz, Eddy Arnold, Xufang Deng, Jun Wang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-02-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-025-56902-x
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