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The Development of LAT1 Efflux Agonists as Mechanistic Probes of Cellular Amino Acid Stress

Amino acid restriction induces cellular stress and cells often respond via the induction of autophagy. Autophagy or ‘self-eating’ enables the recycling of proteins and provides the essential amino acids needed for cell survival. Of the naturally occurring amino acids, methionine restriction has plei...

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Principais autores: Vandana Sekhar, Houssine Ikhlef, Alexandra Bunea, Viet S. Nguyen, Johan Joo, Mukund P. Tantak, Holly Moots, Otto Phanstiel
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2024-03-01
Serier:Biomolecules
Fag:
autophagy
methionine efflux
<i>S</i>-adenosylmethionine (SAM)
lipid signaling
Online adgang:https://www.mdpi.com/2218-273X/14/3/326
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