Treatment strategies for Imerslund-Gräsbeck syndrome: a systematic review of vitamin B12 dosage and routes of administration

Abstract Purpose Imerslund-Gräsbeck syndrome (IGS) is a rare autosomal recessive disorder causing vitamin B12 malabsorption due to variants in CUBN or AMN. Current treatment relies on lifelong B12 supplementation, but standardized protocols are lacking. This systematic review synthesizes reported B1...

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Bibliographic Details

Main Authors:	Amina Hassan, Natasha Partab Rai, Maria Nizamani, Hamida Memon, Hussain Haider Shah
Format:	Artigo
Language:	Inglês
Published:	Springer 2026-02-01
Series:	Journal of Rare Diseases
Subjects:	Imerslund-Gräsbeck syndrome Vitamin B12 deficiency Cobalamin malabsorption AMN/CUBN variants Lifelong supplementation Systematic review
Online Access:	https://doi.org/10.1007/s44162-026-00168-4
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