Genetic and lifestyle modifiers of haemochromatosis-related clinical outcomes in HFE C282Y homozygotes

Background & Aims: The iron overload disease haemochromatosis is primarily caused by HFE p.C282Y homozygosity, yet penetrance of clinical outcomes (including liver disease/cancer) varies. We aimed to estimate the effect of genetic and lifestyle factors on disease penetrance and expressivity in H...

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Autori principali:	Mitchell R. Lucas, João Delgado, Robin N. Beaumont, Gareth Hawkes, Andrew R. Wood, Caroline F. Wright, Jeremy D. Shearman, Janice L. Atkins, Luke C. Pilling
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2026-04-01
Serie:	JHEP Reports
Soggetti:	Hereditary haemochromatosis HFE gene Iron overload Polygenic risk scores Liver disease Genetic modifiers
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2589555926000522
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