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Genetic and lifestyle modifiers of haemochromatosis-related clinical outcomes in HFE C282Y homozygotes

Background & Aims: The iron overload disease haemochromatosis is primarily caused by HFE p.C282Y homozygosity, yet penetrance of clinical outcomes (including liver disease/cancer) varies. We aimed to estimate the effect of genetic and lifestyle factors on disease penetrance and expressivity in H...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Mitchell R. Lucas, João Delgado, Robin N. Beaumont, Gareth Hawkes, Andrew R. Wood, Caroline F. Wright, Jeremy D. Shearman, Janice L. Atkins, Luke C. Pilling
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2026-04-01
Schriftenreihe:JHEP Reports
Schlagworte:
Hereditary haemochromatosis
HFE gene
Iron overload
Polygenic risk scores
Liver disease
Genetic modifiers
Online-Zugang:http://www.sciencedirect.com/science/article/pii/S2589555926000522
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