Energetic Landscape of MDM2-p53 Interactions by Computational Mutagenesis of the MDM2-p53 Interaction.
The ubiquitin ligase MDM2, a principle regulator of the tumor suppressor p53, plays an integral role in regulating cellular levels of p53 and thus a prominent role in current cancer research. Computational analysis used MUMBO to rotamerize the MDM2-p53 crystal structure 1YCR to obtain an exhaustive...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
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Public Library of Science (PLoS)
2016-01-01
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| Schriftenreihe: | PLoS ONE |
| Online-Zugang: | https://doi.org/10.1371/journal.pone.0147806 |
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