Evaluation of 5-[(<i>Z</i>)-(4-nitrobenzylidene)]-2-(thiazol-2-ylimino)-4-thiazolidinone (Les-6222) as Potential Anticonvulsant Agent

It was determined that the studied 5-[(<i>Z</i>)-(4-nitrobenzylidene)]-2-(thiazol-2-ylimino)-4-thiazolidinone (Les-6222) affects the cyclooxygenase pathway of the arachidonic acid cascade, the markers of damage to neurons on models of PTZ kindling. In the model of chronic epileptogenesis in mice (pe...

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Главные авторы:	Mariia Mishchenko, Sergiy Shtrygol’, Andrii Lozynskyi, Mykhailo Hoidyk, Dmytro Khyluk, Tatyana Gorbach, Roman Lesyk
Формат:	Artigo
Язык:	Inglês
Опубликовано:	MDPI AG 2022-09-01
Серии:	Scientia Pharmaceutica
Предметы:	antiepileptic drugs thiazolidinones pentylenetetrazole kindling inflammation molecular docking
Online-ссылка:	https://www.mdpi.com/2218-0532/90/3/56
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