The role of gene duplication and paralog specialisation in the evolution of the mammalian PRPS complex
Abstract The phosphoribosyl pyrophosphate synthetase (PRPS) enzyme catalyzes a chokepoint reaction in nucleotide production, making it essential for life. Here, we show that the presence of multiple PRPS-encoding genes is a hallmark trait of eukaryotes, and we find that gains or losses of paralogs a...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Portfolio
2025-07-01
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| Serie: | Nature Communications |
| Accesso online: | https://doi.org/10.1038/s41467-025-61216-z |
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