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Altered T Follicular Helper Cell Subsets and Function in Chronic Lymphocytic Leukemia

Follicular helper T cells (TFH) have specialized properties in promoting normal B cell activation but their role in chronic lymphocytic leukemia (CLL) is unknown. We find that TFH cells are elevated in CLL patients and are phenotypically abnormal, expressing higher levels of PD-1, TIGIT, CD40L, IFNγ...

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Principais autores: Xun Wu, J. Ernesto Fajardo-Despaigne, Christine Zhang, Vishala Neppalli, Versha Banerji, James B. Johnston, Spencer B. Gibson, Aaron J. Marshall
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021-04-01
Serier:Frontiers in Oncology
Fag:
chronic lymphocytic leukemia (CLL)
T follicular helper (Tfh) cell
interleukin 21 (IL-21)
ibrutinib
TIGIT
coculture assay
Online adgang:https://www.frontiersin.org/articles/10.3389/fonc.2021.674492/full
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