Ustekinumab Inhibits T Follicular Helper Cell Differentiation in Patients With Crohn’s Diseasesummary

Background & aims: The pathogenesis of chronic inflammatory bowel diseases (Crohn’s disease [CD] and ulcerative colitis) involves dysregulated TH1 and TH17 cell responses, which can be targeted therapeutically by the monoclonal antibody Ustekinumab directed against the joint p40 subunit of IL-12...

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Detalhes bibliográficos

Principais autores:	Anna-Maria Globig, Nikola Patricia Sommer, Katharina Wild, Josefine Schardey, Katharina Zoldan, Anne Kerstin Thomann, Lucas-Alexander Schulte, Rupert Schreiner, Wolfgang Reindl, Jochen Klaus, Christoph Mathis Schempp, Maike Hofmann, Robert Thimme, Tobias Boettler, Peter Hasselblatt
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2021-01-01
Colecção:	Cellular and Molecular Gastroenterology and Hepatology
Assuntos:	TFH T Follicular Helper Cell UST Ustekinumab Crohn’s Disease IBD
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2352345X20301119
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