An LQT2-related mutation in the voltage-sensing domain is involved in switching the gating polarity of hERG

Abstract Background Cyclic Nucleotide-Binding Domain (CNBD)-family channels display distinct voltage-sensing properties despite sharing sequence and structural similarity. For example, the human Ether-a-go-go Related Gene (hERG) channel and the Hyperpolarization-activated Cyclic Nucleotide-gated (HC...

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Detalhes bibliográficos

Principais autores:	Zhipei Liu, Feng Wang, Hui Yuan, Fuyun Tian, Chuanyan Yang, Fei Hu, Yiyao Liu, Meiqin Tang, Meixuan Ping, Chunlan Kang, Ting Luo, Guimei Yang, Mei Hu, Zhaobing Gao, Ping Li
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2024-02-01
coleção:	BMC Biology
Assuntos:	hERG K525N Gating Polarity Voltage-Sensing Domain LQT2
Acesso em linha:	https://doi.org/10.1186/s12915-024-01833-0
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