Correction of dysregulated lipid metabolism normalizes gene expression in oligodendrocytes and prolongs lifespan in female poly-GA C9orf72 mice

Abstract Clinical and genetic research links altered cholesterol metabolism with ALS development and progression, yet pinpointing specific pathomechanisms remain challenging. We investigated how cholesterol dysmetabolism interacts with protein aggregation, demyelination, and neuronal loss in ALS. Bu...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Ali Rezaei, Virág Kocsis-Jutka, Zeynep I. Gunes, Qing Zeng, Georg Kislinger, Franz Bauernschmitt, Huseyin Berkcan Isilgan, Laura R. Parisi, Tuğberk Kaya, Sören Franzenburg, Jonas Koppenbrink, Julia Knogler, Thomas Arzberger, Daniel Farny, Brigitte Nuscher, Eszter Katona, Ashutosh Dhingra, Chao Yang, Garyfallia Gouna, Katherine D. LaClair, Aleksandar Janjic, Wolfgang Enard, Qihui Zhou, Nellwyn Hagan, Dimitry Ofengeim, Eduardo Beltrán, Ozgun Gokce, Mikael Simons, Sabine Liebscher, Dieter Edbauer
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Nature Portfolio 2025-04-01
Sarja:	Nature Communications
Linkit:	https://doi.org/10.1038/s41467-025-58634-4
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