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NL101 synergizes with the BCL-2 inhibitor venetoclax through PI3K-dependent suppression of c-Myc in acute myeloid leukaemia

Abstract Background Acute myeloid leukaemia (AML) comprises a group of heterogeneous and aggressive haematological malignancies with unsatisfactory prognoses and limited treatment options. Treatments targeting B-cell lymphoma-2 (BCL-2) with venetoclax have been approved for patients with AML, and ve...

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Principais autores: Ying Lu, Xia Jiang, Youhong Li, Fenglin Li, Mengting Zhao, Ye Lin, Lili Jin, Haihui Zhuang, Shuangyue Li, Peipei Ye, Renzhi Pei, Jie Jin, Lei Jiang
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2024-09-01
coleção:Journal of Translational Medicine
Assuntos:
AML
NL101
Venetoclax
Apoptosis
MCL-1
c-Myc
Acesso em linha:https://doi.org/10.1186/s12967-024-05647-0
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