Engineering Af1521 improves ADP-ribose binding and identification of ADP-ribosylated proteins

ADP-ribose binding macro domains facilitate the enrichment and detection of cellular ADP-ribosylation. Here, the authors generate an engineered macro domain with increased ADP-ribose affinity, improving the identification of ADP-ribosylated proteins by proteomics, western blot and immunofluorescence...

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Detaylı Bibliyografya
Asıl Yazarlar:	Kathrin Nowak, Florian Rosenthal, Tobias Karlberg, Mareike Bütepage, Ann-Gerd Thorsell, Birgit Dreier, Jonas Grossmann, Jens Sobek, Ralph Imhof, Bernhard Lüscher, Herwig Schüler, Andreas Plückthun, Deena M. Leslie Pedrioli, Michael O. Hottiger
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	Nature Portfolio 2020-10-01
Seri Bilgileri:	Nature Communications
Online Erişim:	https://doi.org/10.1038/s41467-020-18981-w
Etiketler:	Etiketle Etiket eklenmemiş, İlk siz ekleyin!

Engineering Af1521 improves ADP-ribose binding and identification of ADP-ribosylated proteins

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