Senescent Schwann cells induced by aging and chronic denervation impair axonal regeneration following peripheral nerve injury

Abstract Following peripheral nerve injury, successful axonal growth and functional recovery require Schwann cell (SC) reprogramming into a reparative phenotype, a process dependent upon c‐Jun transcription factor activation. Unfortunately, axonal regeneration is greatly impaired in aged organisms a...

Fuld beskrivelse

Bibliografiske detaljer

Principais autores:	Andrés Fuentes‐Flores, Cristian Geronimo‐Olvera, Karina Girardi, David Necuñir‐Ibarra, Sandip Kumar Patel, Joanna Bons, Megan C Wright, Daniel Geschwind, Ahmet Hoke, Jose A Gomez‐Sanchez, Birgit Schilling, Daniela L Rebolledo, Judith Campisi, Felipe A Court
Format:	Artigo
Sprog:	Inglês
Udgivet:	Springer Nature 2023-10-01
Serier:	EMBO Molecular Medicine
Fag:	aging chronic denervation nerve regeneration Schwann cell senescence
Online adgang:	https://doi.org/10.15252/emmm.202317907
Tags:	Tilføj Tag Ingen Tags, Vær først til at tagge denne postø!