Peptide Model of the Mutant Proinsulin Syndrome. II. Nascent Structure and Biological Implications

Toxic misfolding of proinsulin variants in β-cells defines a monogenic diabetes syndrome, designated mutant INS-gene induced diabetes of the young (MIDY). In our first study (previous article in this issue), we described a one-disulfide peptide model of a proinsulin folding intermediate and its use...

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Principais autores:	Yanwu Yang, Michael D. Glidden, Balamurugan Dhayalan, Alexander N. Zaykov, Yen-Shan Chen, Nalinda P. Wickramasinghe, Richard D. DiMarchi, Michael A. Weiss
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2022-03-01
Series:	Frontiers in Endocrinology
Assuntos:	monogenic diabetes peptide chemistry protein folding folding nucleus oxidative folding intermediate NMR spectroscopy
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fendo.2022.821091/full
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