Mitochondrial Dysfunction Inhibits Hypoxia-Induced HIF-1α Stabilization and Expression of Its Downstream Targets

mtDNA variations often result in bioenergetic dysfunction inducing a metabolic switch toward glycolysis resulting in an unbalanced pH homeostasis. In hypoxic cells, expression of the tumor-associated carbonic anhydrase IX (CAIX) is enhanced to maintain cellular pH homeostasis. We hypothesized that c...

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Autori principali:	Marike W. van Gisbergen, Kelly Offermans, An M. Voets, Natasja G. Lieuwes, Rianne Biemans, Roland F. Hoffmann, Ludwig J. Dubois, Philippe Lambin
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2020-05-01
Serie:	Frontiers in Oncology
Soggetti:	mtDNA mitochondria OXPHOS CAIX HIF-1α Metformin
Accesso online:	https://www.frontiersin.org/article/10.3389/fonc.2020.00770/full
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