Aneuploidy as a cause of impaired chromatin silencing and mating-type specification in budding yeast

Aneuploidy and epigenetic alterations have long been associated with carcinogenesis, but it was unknown whether aneuploidy could disrupt the epigenetic states required for cellular differentiation. In this study, we found that ~3% of random aneuploid karyotypes in yeast disrupt the stable inheritanc...

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Hlavní autoři:	Wahid A Mulla, Chris W Seidel, Jin Zhu, Hung-Ji Tsai, Sarah E Smith, Pushpendra Singh, William D Bradford, Scott McCroskey, Anjali R Nelliat, Juliana Conkright, Allison Peak, Kathryn E Malanowski, Anoja G Perera, Rong Li
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	eLife Sciences Publications Ltd 2017-08-01
Edice:	eLife
Témata:	aneuploidy epigenetic instability chromatin silencing cellular differentiation
On-line přístup:	https://elifesciences.org/articles/27991
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