Aneuploidy as a cause of impaired chromatin silencing and mating-type specification in budding yeast

Aneuploidy and epigenetic alterations have long been associated with carcinogenesis, but it was unknown whether aneuploidy could disrupt the epigenetic states required for cellular differentiation. In this study, we found that ~3% of random aneuploid karyotypes in yeast disrupt the stable inheritanc...

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Opis bibliograficzny

Główni autorzy:	Wahid A Mulla, Chris W Seidel, Jin Zhu, Hung-Ji Tsai, Sarah E Smith, Pushpendra Singh, William D Bradford, Scott McCroskey, Anjali R Nelliat, Juliana Conkright, Allison Peak, Kathryn E Malanowski, Anoja G Perera, Rong Li
Format:	Artigo
Język:	Inglês
Wydane:	eLife Sciences Publications Ltd 2017-08-01
Seria:	eLife
Hasła przedmiotowe:	aneuploidy epigenetic instability chromatin silencing cellular differentiation
Dostęp online:	https://elifesciences.org/articles/27991
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