Structure-Based Modification of an Anti-neuraminidase Human Antibody Restores Protection Efficacy against the Drifted Influenza Virus

ABSTRACT Here, we investigate a monoclonal antibody, Z2B3, isolated from an H7N9-infected patient, that exhibited cross-reactivity to both N9 (group 2) and a broad range of seasonal and avian N1 (group 1) proteins but lost activity to the N1 with the substitution K432E. This substitution exists in 9...

Descripció completa

Dades bibliogràfiques

Autors principals:	Haihai Jiang, Weiyu Peng, Jianxun Qi, Yan Chai, Hao Song, Yuhai Bi, Pramila Rijal, Haiyuan Wang, Babayemi O. Oladejo, Jinhua Liu, Yi Shi, George F. Gao, Alain R. Townsend, Yan Wu
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology 2020-10-01
Col·lecció:	mBio
Matèries:	influenza neuraminidase neutralizing antibody structure-based modification
Accés en línia:	https://journals.asm.org/doi/10.1128/mBio.02315-20
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!