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New piperazine multi-effect drugs prevent neurofibrillary degeneration and amyloid deposition, and preserve memory in animal models of Alzheimer's disease

Alzheimer's Disease is a devastating dementing disease involving amyloid deposits, neurofibrillary tangles, progressive and irreversible cognitive impairment. Today, only symptomatic drugs are available and therapeutic treatments, possibly acting at a multiscale level, are thus urgently needed. To t...

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Sábháilte in:
Príomhchruthaitheoirí: Nicolas Sergeant, Valérie Vingtdeux, Sabiha Eddarkaoui, Marion Gay, Caroline Evrard, Nicolas Le Fur, Cyril Laurent, Raphaelle Caillierez, Hélène Obriot, Paul-Emmanuel Larchanché, Amaury Farce, Mathilde Coevoet, Pascal Carato, Mostafa Kouach, Amandine Descat, Patrick Dallemagne, Valérie Buée-Scherrer, David Blum, Malika Hamdane, Luc Buée, Patricia Melnyk
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Elsevier 2019-09-01
Sraith:Neurobiology of Disease
Ábhair:
Alzheimer's disease
Amyloid
Microtubule-associated protein tau
Multi-effect drugs
Neurofibrillary tangles
Tauopathies
Rochtain ar líne:http://www.sciencedirect.com/science/article/pii/S0969996118303279
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