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Differential expression of VEGFR2 protein in HER2 positive primary human breast cancer: potential relevance to anti-angiogenic therapies

Abstract Background Clinically relevant predictive biomarkers to tailor anti-angiogenic therapies to breast cancer (BRC) patient subpopulations are an unmet need. Methods We analyzed tumor vascular density and VEGFR2 protein expression in various subsets of primary human BRCs (186 females; Mean age:...

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Autori principali: Aejaz Nasir, Timothy R. Holzer, Mia Chen, Michael Z. Man, Andrew E. Schade
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2017-05-01
Serie:Cancer Cell International
Soggetti:
Breast cancer
HER2
Angiogenesis
VEGFR2
Ramucirumab
Antiangiogenic therapy
Accesso online:http://link.springer.com/article/10.1186/s12935-017-0427-5
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