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Immediate protective effect of rUCMSC-EVs on ovarian function in a cyclophosphamide -induced premature ovarian insufficiency rats: counteracting granulosa cell apoptosis

Abstract Backgrounds Premature ovarian insufficiency (POI), which is defined as the loss of ovarian activity before the age of 40 leading to amenorrhea and infertility, is often induced in female patients treated with alkylating agents such as cyclophosphamide (CTX). Currently, the standard clinical...

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Main Authors: Zelan Yang, Cheng Zou, Yufei Deng, Hanyu Xiao, Yan Zou, Zhibiao Wang, Liaoqiong Fang, Jin Bai
Format: Artigo
Language:Inglês
Published: BMC 2026-04-01
Series:Journal of Ovarian Research
Subjects:
Cyclophosphamide
Premature ovarian insufficiency
Extracellular vesicles
Apoptosis
DNA repair
Online Access:https://doi.org/10.1186/s13048-026-02119-5
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