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Pluronic F-127/Propylene Glycol Binary Building Blocks for Novel Solid Dispersion Matrix: Industrial and Ecological Paradigm to Enhance Dissolution Profile of Dapagliflozin

<b>Background/Objectives</b>: The limited aqueous solubility of therapeutically active drugs remains a significant challenge in their pharmaceutical application. This study presents a novel solid dispersion matrix (NSDM) that utilizes the inverted thermoresponsive behavior of Pluronic F127 to enhanc...

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Principais autores: Abdelrahman Y. Sherif, Mohammad A. Altamimi, Ehab M. Elzayat
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2026-04-01
Serier:Pharmaceutics
Fag:
novel solid dispersion matrix
thermoresponsive polymer
dapagliflozin
pluronic F-127
propylene glycol
drug amorphization
Online adgang:https://www.mdpi.com/1999-4923/18/5/560
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