Pluronic F-127/Propylene Glycol Binary Building Blocks for Novel Solid Dispersion Matrix: Industrial and Ecological Paradigm to Enhance Dissolution Profile of Dapagliflozin

<b>Background/Objectives</b>: The limited aqueous solubility of therapeutically active drugs remains a significant challenge in their pharmaceutical application. This study presents a novel solid dispersion matrix (NSDM) that utilizes the inverted thermoresponsive behavior of Pluronic F127 to enhanc...

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Hauptverfasser:	Abdelrahman Y. Sherif, Mohammad A. Altamimi, Ehab M. Elzayat
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2026-04-01
Schriftenreihe:	Pharmaceutics
Schlagworte:	novel solid dispersion matrix thermoresponsive polymer dapagliflozin pluronic F-127 propylene glycol drug amorphization
Online-Zugang:	https://www.mdpi.com/1999-4923/18/5/560
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