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Evidence of Orientation-Dependent Early States of Prion Protein Misfolded Structures from Single Molecule Force Spectroscopy

Prion diseases are neurodegenerative disorders characterized by the presence of oligomers and amyloid fibrils. These are the result of protein aggregation processes of the cellular prion protein (PrP<sup>C</sup>) into amyloidal forms denoted as prions or PrP<sup>Sc</sup>. We employed atomic force mi...

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Principais autores: Andrea Raspadori, Valentina Vignali, Anna Murello, Gabriele Giachin, Bruno Samorì, Motomasa Tanaka, Carlos Bustamante, Giampaolo Zuccheri, Giuseppe Legname
פורמט: Artigo
שפה:Inglês
יצא לאור: MDPI AG 2022-09-01
סדרה:Biology
נושאים:
prions
atomic force microscopy
single molecule force spectroscopy
protein misfolding
intrinsically disordered proteins
גישה מקוונת:https://www.mdpi.com/2079-7737/11/9/1358
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